GABA and mood disorders
نویسندگان
چکیده
منابع مشابه
MOOD DISORDERS AND MEDICAL ILLNESS Mood Disorders and Allostatic Load
The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the nervous system is itself a target of the mediators of those responses through circulating hormones. The amygdala and hippocampus interpret what is stressful and regulate appropriate responses. The amygdala becomes hyperactive in posttraumatic stress disorder (PTSD) and...
متن کاملGABA and neuropsychiatric disorders.
Because GABA appears to be an important, if not the primary, inhibitory neurotransmitter in brain, it is not surprising to find biochemical, physiological and behavioral data indicating that activation of the GABAergic system may be efficacious in the treatment of epilepsy (Meldrum, 1975). In addition, a significant loss of GABA neurons has been noted around the seizure foci in monkey cortex af...
متن کاملChronobiology and mood disorders
The clinical observations of diurnal variation of mood and early morning awakening in depression have been incorporated into established diagnostic systems, as has the seasonal modifier defining winter depression (seasonal affective disorder, SAD). Many circadian rhythms measured in depressive patients are abnormal: earlier in timing, diminished in amplitude, or of greater variability. Whether ...
متن کاملGABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies
Third-generation neuroimaging research has been enriched by advances in magnetic resonance spectroscopy (MRS) measuring the concentration of important neurotrasmitters, such as the inhibitory amino acid GABA. Here, we performed a systematic mini-review on brain MRS studies measuring GABA concentration in patients affected by schizophrenia (SZ), bipolar disorder (BD), and major depressive disord...
متن کاملManaging mood disorders and comorbid personality disorders.
PURPOSE OF REVIEW To examine the influence of personality disorder comorbidity on the general treatment of mood disorders. RECENT FINDINGS Personality disorders generally have a negative influence on outcome of mood disorders, both unipolar and bipolar. When the personality features are addressed, however, the outcome is less negative. Recent studies suggest a special role for psychological a...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2003
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291702006876